Free General Pharmacology MCQs with Answers

• A. Lorazepam
• B. Theophylline
• C. Paracetamol
• D. Metronidazole

Explanation: Lorazepam is mainly inactivated by conjugation and is relatively unaffected by hepatic oxidation, so it generally needs no dose reduction…

• A. 1 - 18 days
• B. 19 - 55 days
• C. 56 - 85 days
• D. II trimester

Explanation: The major teratogenic period is the embryonic organogenesis stage, approximately weeks 3 to 8, corresponding most closely to days 19 to…

• A. Dextrose
• B. Dilantine
• C. Diazepam
• D. Dopamine

Explanation: Dopamine is polar and does not cross the blood-brain barrier, which is why it cannot directly produce central dopaminergic effects.

• A. Carcinoma forming tendency
• B. Fetal malformation
• C. Intolerance to a drug
• D. Drug dependence

Explanation: Teratogenicity is the capacity of a drug or exposure to cause fetal developmental abnormalities or malformations.

• A. H1 histamine receptor antagonist
• B. H2 histamine receptor antagonist
• C. Adrenal steroids
• D. Anticholinergic

Explanation: H2-receptor antagonists directly block histamine-stimulated acid secretion by gastric parietal cells and reduce basal and meal-stimulated…

• A. Carcinogens
• B. Allergens
• C. Nontherapeutic agents
• D. All of the above

Explanation: Drug injury may result from therapeutic medicines or nontherapeutic chemical agents, including accidental or environmental exposures.

• A. Increase in IL-1
• B. Increase in total amount of circulatory neutrophils
• C. Anti-inflammatory effect is increased
• D. Inhibit phospholipase A2

Explanation: Corticosteroids decrease IL-1 production, inhibit phospholipase A2 through lipocortin induction, and produce anti-inflammatory effects…

• A. Montelukast
• B. Zileuton
• C. Nedocromil
• D. Misopristol

Explanation: Montelukast blocks cysteinyl-leukotriene receptors and is therefore a leukotriene antagonist.

• A. Metaclopramide
• B. INH
• C. Dapsone
• D. Hydralazine

Explanation: Metoclopramide is not a clinically important acetylation substrate, whereas isoniazid, dapsone and hydralazine undergo acetylation with…

• A. Pencillins
• B. Sulfonamides
• C. Certrizine
• D. Cephalosporins

Explanation: Penicillins, sulfonamides and cephalosporins are well-known causes of drug hypersensitivity.

• A. Insulin
• B. Chloral hydrate
• C. Procaine
• D. Streptomycin

Explanation: Chloral hydrate is absorbed after oral administration and produces systemic sedative-hypnotic effects.

• A. Bleeding gums
• B. Alkaloidal poisoning
• C. Toothache
• D. Bleeding piles

Explanation: Tannic acid acts as a local astringent and has been used for bleeding gums, bleeding piles and as an older treatment for alkaloidal…

• A. Blood coagulant
• B. Astrigent
• C. Styptic
• D. All of the following

Explanation: Tannic acid precipitates surface proteins, producing an astringent effect that contracts tissues and reduces secretions.

• A. Cumulation
• B. Induction
• C. Synergism
• D. Antagonism

Explanation: Synergism occurs when the combined effect of two drugs is greater than the effect produced by either drug alone.

• A. An agonist
• B. A non competitive antagonist
• C. A physiologic antagonist
• D. A competitive antagonist

Explanation: An agonist binds to a receptor and activates it, producing intrinsic activity.

• A. Oral
• B. Inhalation
• C. Rectal
• D. Parental

Explanation: Orally administered drugs pass from the gut through the portal circulation to the liver before reaching systemic circulation, producing a…

• A. Weight of the child
• B. Age of child
• C. Nature of the drug
• D. Chronicity of pain

Explanation: Drug doses in children are commonly calculated according to body weight, such as mg/kg, because children differ considerably in size and…

• A. Enalapril
• B. clonidine
• C. Salmeterol
• D. Acetazolamide

Explanation: Enalapril is converted in the body to the active ACE inhibitor enalaprilat, making it a prodrug.

• A. 12 hrs
• B. 20 hrs
• C. 25 hrs
• D. 30 hrs

Explanation: After five half-lives, about 97% of a drug has been eliminated and this is conventionally treated as complete elimination.

• A. Super sensitivity
• B. Idiosyncrasy
• C. Hyper sensitivity
• D. Hyper acidity

Explanation: An immune-mediated abnormal response to a drug is called hypersensitivity, such as an allergic reaction.