1st past metabolism effect can be observed with which route______________?
Correct answer: A. Oral
- A. Oral
- B. Inhalation
- C. Rectal
- D. Parental
Explanation
Orally administered drugs pass from the gut through the portal circulation to the liver before reaching systemic circulation, producing a first-pass effect. Rectal administration partly avoids this effect, while inhaled and parenteral routes generally bypass it.
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