Which of the following is NOT a systemic effect of corticosteroid ?
Correct answer: A. Increase in IL-1
- A. Increase in IL-1
- B. Increase in total amount of circulatory neutrophils
- C. Anti-inflammatory effect is increased
- D. Inhibit phospholipase A2
Explanation
Corticosteroids decrease IL-1 production, inhibit phospholipase A2 through lipocortin induction, and produce anti-inflammatory effects; they also increase circulating neutrophils by demargination. Thus, an increase in IL-1 is the untrue statement.
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