In cirrhoses patients, dose reduction is needed for all the following drugs except_____________?
Correct answer: A. Lorazepam
- A. Lorazepam
- B. Theophylline
- C. Paracetamol
- D. Metronidazole
Explanation
Lorazepam is mainly inactivated by conjugation and is relatively unaffected by hepatic oxidation, so it generally needs no dose reduction in cirrhosis. Theophylline, paracetamol and metronidazole require caution or dose adjustment because hepatic dysfunction can increase toxicity.
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