All Free Pharmacology MCQs with Answers

• A. Less thrombophlebitis due to low solubility in blond
• B. More plasma binding and less toxicity
• C. More potent than diazepam
• D. Binds to benzodiazepine receptors with 3-4 time more avidly

Explanation: Midazolam is more potent than diazepam, more water-soluble in its injectable formulation and produces less venous irritation; it is also…

• A. Prostaglandin synthesis
• B. Ectoglandin synthesis
• C. Preglandin synthesis
• D. Costaglandin synthesis

Explanation: Cyclooxygenase converts arachidonic acid toward prostaglandin and thromboxane production, so NSAID inhibition reduces prostaglandin…

• A. Aspirin and Codeine
• B. Paracetamol and Dextropropoxyphene
• C. Ibuprofen and Paracetamol
• D. Ibuprofen and DIclofenac

Explanation: Ibuprofen and diclofenac are both NSAIDs, so combining them duplicates cyclooxygenase inhibition without providing proportional benefit…

• A. Chlorpheniramine
• B. Chlorpromazine
• C. Chloroquine
• D. Chlorhexidine

Explanation: Chlorpromazine blocks dopamine D2 receptors in the nigrostriatal pathway, producing extrapyramidal effects such as drug-induced…

• A. Olanzepine
• B. Clozapine
• C. Risperidone
• D. Thioridazone

Explanation: Olanzapine, clozapine and risperidone are atypical antipsychotics with relatively lower extrapyramidal liability.

• A. Flumazenil
• B. Furazolidone
• C. Naloxone
• D. Naltrexone

Explanation: Flumazenil competitively antagonizes the benzodiazepine binding site on the GABA-A receptor and reverses benzodiazepine sedation.

• A. Bromocriptine
• B. Lysergic acid diethylamide (LSD)
• C. Ketanserin
• D. Methysergide

Explanation: Bromocriptine, LSD and methysergide are ergot derivatives or semisynthetic ergot compounds.

• A. Produce distortion in sleep more than other sedatives
• B. More safe than other sedatives when take in larger amounts
• C. After metabolism of other drugs in liver
• D. All have metabolically active substrates

Explanation: Benzodiazepines have a relatively wide safety margin and are less likely than barbiturates to cause fatal respiratory depression in…

• A. Atracurium
• B. Vecuronium
• C. Rocuronium
• D. Doxacurium

Explanation: Doxacurium is a long-acting non-depolarizing neuromuscular blocker. Atracurium, vecuronium and rocuronium have shorter durations of action…

• A. Diarrhea
• B. Lacrimation
• C. Mydriasis
• D. Excessive speech

Explanation: Opioid withdrawal causes autonomic overactivity, including diarrhea, lacrimation and dilated pupils.

• A. Mu receptor antagonist
• B. Kappa receptor antagonist
• C. Mu receptor partial agnoist
• D. Kappa receptor partial agonist

Explanation: Buprenorphine is a high-affinity partial agonist at mu opioid receptors, producing analgesia with a ceiling effect on respiratory…

• A. Meprobamate
• B. Pentobarbital
• C. Trimethadione
• D. Phenytoin

Explanation: Phenytoin is a standard treatment for generalized tonic-clonic, or grand-mal, seizures because it limits repetitive neuronal firing by…

• A. Tranquilizers
• B. Non-barbiturates
• C. Synthetic narcotics
• D. Antidepressants

Explanation: Synthetic opioids such as morphine-like narcotic analgesics can markedly depress the medullary respiratory centre, especially in overdose.

• A. Phentoin sodium
• B. Carbamazepine
• C. Phenobarbitone
• D. None of the above

Explanation: This appears to mean petit-mal, or absence, seizures, for which ethosuximide is the usual first-choice drug.

• A. A marked increase in blood pressure
• B. Rigidity and tremor at rest, particularly with prolonged use
• C. Suppression of prolacin
• D. Nausea

Explanation: Phenothiazines can block dopamine receptors in the nigrostriatal pathway, producing extrapyramidal effects such as rigidity and resting…

• A. Cerebral cortex
• B. Corpus callosum
• C. Hypothalamus
• D. Spinal cord

Explanation: Caffeine chiefly stimulates the cerebral cortex, producing increased alertness and reduced fatigue by blocking adenosine receptors.

• A. Phenobarbitonse
• B. Dilantoin sodium
• C. Diazepam
• D. Ethosuximide

Explanation: Ethosuximide is the classic drug for absence, formerly called petit mal, seizures because it suppresses thalamic T-type calcium currents.

• A. Acetylcholine
• B. Ergotamine
• C. Morphine
• D. Ibuprofen

Explanation: Ergotamine can terminate an acute migraine by producing vasoconstriction and counteracting cranial vascular dilation.

• A. Meprobamate
• B. Pentobarbitone
• C. Thiopentone
• D. Phenobarbitone

Explanation: Thiopentone is an intravenous ultrashort-acting barbiturate used for rapid induction of anaesthesia.

• A. Ethosuximide
• B. Phenobarbitone
• C. Sodium valporate
• D. None of the above

Explanation: Gingival hyperplasia is a classic reversible adverse effect of phenytoin, but phenytoin is not listed among the options.