True about use of midazolam over diazepam is sedation in all except ?

Correct answer: D. Binds to benzodiazepine receptors with 3-4 time more avidly

  • A. Less thrombophlebitis due to low solubility in blond
  • B. More plasma binding and less toxicity
  • C. More potent than diazepam
  • D. Binds to benzodiazepine receptors with 3-4 time more avidly

Explanation

Midazolam is more potent than diazepam, more water-soluble in its injectable formulation and produces less venous irritation; it is also highly protein-bound. The claim that it binds benzodiazepine receptors three to four times more avidly is not the standard distinguishing feature and is the exception.

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