Free Central Nervous System Drugs MCQs with Answers

• A. Bromocriptine
• B. Lysergic acid diethylamide (LSD)
• C. Ketanserin
• D. Methysergide

Explanation: Bromocriptine, LSD and methysergide are ergot derivatives or semisynthetic ergot compounds.

• A. Produce distortion in sleep more than other sedatives
• B. More safe than other sedatives when take in larger amounts
• C. After metabolism of other drugs in liver
• D. All have metabolically active substrates

Explanation: Benzodiazepines have a relatively wide safety margin and are less likely than barbiturates to cause fatal respiratory depression in…

• A. Atracurium
• B. Vecuronium
• C. Rocuronium
• D. Doxacurium

Explanation: Doxacurium is a long-acting non-depolarizing neuromuscular blocker. Atracurium, vecuronium and rocuronium have shorter durations of action…

• A. Diarrhea
• B. Lacrimation
• C. Mydriasis
• D. Excessive speech

Explanation: Opioid withdrawal causes autonomic overactivity, including diarrhea, lacrimation and dilated pupils.

• A. Mu receptor antagonist
• B. Kappa receptor antagonist
• C. Mu receptor partial agnoist
• D. Kappa receptor partial agonist

Explanation: Buprenorphine is a high-affinity partial agonist at mu opioid receptors, producing analgesia with a ceiling effect on respiratory…

• A. Meprobamate
• B. Pentobarbital
• C. Trimethadione
• D. Phenytoin

Explanation: Phenytoin is a standard treatment for generalized tonic-clonic, or grand-mal, seizures because it limits repetitive neuronal firing by…

• A. Tranquilizers
• B. Non-barbiturates
• C. Synthetic narcotics
• D. Antidepressants

Explanation: Synthetic opioids such as morphine-like narcotic analgesics can markedly depress the medullary respiratory centre, especially in overdose.

• A. Phentoin sodium
• B. Carbamazepine
• C. Phenobarbitone
• D. None of the above

Explanation: This appears to mean petit-mal, or absence, seizures, for which ethosuximide is the usual first-choice drug.

• A. A marked increase in blood pressure
• B. Rigidity and tremor at rest, particularly with prolonged use
• C. Suppression of prolacin
• D. Nausea

Explanation: Phenothiazines can block dopamine receptors in the nigrostriatal pathway, producing extrapyramidal effects such as rigidity and resting…

• A. Cerebral cortex
• B. Corpus callosum
• C. Hypothalamus
• D. Spinal cord

Explanation: Caffeine chiefly stimulates the cerebral cortex, producing increased alertness and reduced fatigue by blocking adenosine receptors.

• A. Phenobarbitonse
• B. Dilantoin sodium
• C. Diazepam
• D. Ethosuximide

Explanation: Ethosuximide is the classic drug for absence, formerly called petit mal, seizures because it suppresses thalamic T-type calcium currents.

• A. Acetylcholine
• B. Ergotamine
• C. Morphine
• D. Ibuprofen

Explanation: Ergotamine can terminate an acute migraine by producing vasoconstriction and counteracting cranial vascular dilation.

• A. Meprobamate
• B. Pentobarbitone
• C. Thiopentone
• D. Phenobarbitone

Explanation: Thiopentone is an intravenous ultrashort-acting barbiturate used for rapid induction of anaesthesia.

• A. Ethosuximide
• B. Phenobarbitone
• C. Sodium valporate
• D. None of the above

Explanation: Gingival hyperplasia is a classic reversible adverse effect of phenytoin, but phenytoin is not listed among the options.

• A. Use in head injury patient
• B. use in impaired pulmonary function
• C. Use of agonist with mixed agonist-antagonist
• D. Use in severe constant pain

Explanation: Severe constant pain is an indication for opioid analgesia, whereas head injury and impaired pulmonary function increase the danger of…

• A. Pulmonary oedema
• B. Emphysema
• C. Bronchial asthma
• D. Head injury

Explanation: Morphine may be used in acute pulmonary oedema because it reduces anxiety and venous return, thereby lowering cardiac preload.

• A. Phenobarbitone
• B. Phenytoin sodium
• C. Primidone
• D. Carbamazepine

Explanation: Carbamazepine is the preferred traditional drug for temporal-lobe, or focal impaired-awareness, epilepsy; phenytoin and phenobarbitone are…

• A. Prochlorperazine
• B. Carbamezapine
• C. Diphenhydramine
• D. Ciprofloxacin

Explanation: Prochlorperazine can produce acute dystonic reactions because of dopamine D2 blockade, causing jaw spasm, trismus, or even mandibular…

• A. Used in trigeminal neuralgia
• B. Carbamazepine is an enzyme inhibitor
• C. Can cause megaloblastic anemia
• D. It is the drug of choice for status epilepticus

Explanation: Carbamazepine is a classic treatment for trigeminal neuralgia and is also useful in focal seizures.

• A. Grand mal epilepsy
• B. Infantile spasm
• C. Petit mal
• D. None of the above

Explanation: Absence, or petit-mal, epilepsy is classically common in school-aged children and presents with brief staring spells.