All Free Pharmacology MCQs with Answers

• A. Anaerobic
• B. Gram positive organism
• C. Gram negative organisms
• D. Yeast and fungi

Explanation: Broad-spectrum antibiotics suppress much of the normal bacterial flora, removing competition and allowing Candida and other fungi to…

• A. Higher oral biovailability
• B. Lower oral biovailability
• C. Equal oral biovailability
• D. Can be given Parenterally

Explanation: Amoxicillin has higher and more reliable oral bioavailability than ampicillin, so food has less effect on its absorption and…

• A. Gentamycin
• B. Tetracycline
• C. Aztreonam
• D. Neomycin

Explanation: Neomycin is an aminoglycoside commonly combined with polymyxin and bacitracin in topical preparations for mixed bacterial skin infections.

• A. Burns
• B. Tinea
• C. Non-specific vaginitis
• D. All of the above

Explanation: Povidone-iodine is a broad-spectrum antiseptic used on burns, has antifungal activity in conditions such as tinea, and is also used…

• A. Penicillin
• B. Imipenem
• C. Cephalosporins
• D. All of the above

Explanation: Beta-lactam antibiotics contain a beta-lactam ring and include penicillins, cephalosporins, and carbapenems such as imipenem.

• A. Nystatin
• B. Amphotericin
• C. Interferons
• D. Thiobendazole

Explanation: Disseminated candidiasis is a serious systemic fungal infection requiring an intensive systemic antifungal, classically amphotericin B.

• A. Increased excretion of probenacid in the feaces and perspiration
• B. Increased excretion of probenacid in urine
• C. Increased metabolis of penciling G
• D. Decreased renal excretion of penciling G

Explanation: Probenecid inhibits renal tubular secretion of penicillin G, reducing its renal excretion and prolonging its plasma half-life.

• A. Cephalexin
• B. Cloxacillin
• C. Piperacillin
• D. Dictoxacillin

Explanation: Piperacillin is an extended-spectrum antipseudomonal penicillin, often combined with tazobactam.

• A. Cefoperazone
• B. Cefaclor
• C. Ceftriaxone
• D. Cefotaxime

Explanation: Cefoperazone is a third-generation cephalosporin with important activity against Pseudomonas aeruginosa.

• A. Suphacetamide
• B. Sulphadiazine
• C. Silversulphadiazine
• D. Mafenide

Explanation: Sulfacetamide, silver sulfadiazine, and mafenide are used topically, particularly for ocular, burn, or local wound infections.

• A. Amoxicillin
• B. Penicillin G
• C. Piperacillin
• D. Cloxacillin

Explanation: Cloxacillin is resistant to staphylococcal penicillinase because of its sterically protected beta-lactam ring.

• A. Carbapenems
• B. Monobactams
• C. Cephamycins
• D. Nitrofurantoins

Explanation: Carbapenems, monobactams, and cephamycins inhibit bacterial cell-wall synthesis by targeting penicillin-binding proteins.

• A. Protease inhibitor
• B. Nucleoside reverse transcriptase inhibitor
• C. Non-nucleoside reverse transcriptase inhibitor
• D. Fusion inhibitor

Explanation: Nevirapine binds to and inhibits HIV reverse transcriptase without competing with nucleosides, so it is a non-nucleoside reverse…

• A. Vancomycin
• B. Imipenem
• C. Teichoplanin
• D. Linezolid

Explanation: MRSA is resistant to methicillin and generally to other beta-lactams, including carbapenems such as imipenem.

• A. Clotrimazole
• B. Clotrimoxazole
• C. Ornidazole
• D. Propronolol

Explanation: Clotrimazole is an imidazole antifungal available as a topical preparation for candidiasis.

• A. Granulocytes
• B. Immunoglobulins
• C. Opsonins
• D. T lymphocytes

Explanation: HIV primarily destroys CD4-positive T helper lymphocytes, producing progressive impairment of cell-mediated immunity.

• A. 30S ribosomes
• B. 50S ribosomes
• C. Cell membrane
• D. Inhibiting DNA gyrase

Explanation: Tetracyclines bind reversibly to the 30S bacterial ribosomal subunit and prevent attachment of aminoacyl-tRNA.

• A. Atovaquone + Proguanil
• B. Artemisinin
• C. Quinine + Tetracycline
• D. Pyrimethamine + Sulfadoxime

Explanation: Pyrimethamine with sulfadoxine was classically administered as a single-dose treatment for malaria, although it does not provide radical…

• A. Erythromycin
• B. Roxithromycin
• C. Neomycin
• D. Calithromycin

Explanation: Erythromycin, roxithromycin and clarithromycin are macrolides that inhibit bacterial protein synthesis at the 50S subunit.

• A. Destroyed by gastic acid
• B. Very active against sensitive gram positive coci
• C. Used for treatment of meningococcal meningitis
• D. More concentrated in prostatic secretion and intraocular fluids

Explanation: Penicillin G is acid-labile, active against susceptible gram-positive cocci and historically used intravenously for meningococcal…