Free Oral Manifestations of Systemic Disease MCQs with Answers

• A. protein metabolism
• B. Carbohydrate metabolism
• C. Mucopolysaccharide metabolism
• D. histiocytic disorder

Explanation: Letterer-Siwe disease is an acute disseminated form of Langerhans cell histiocytosis, so it represents a histiocytic disorder.

• A. Hyperparathyroidism
• B. Cushing's syndorme
• C. Multiple myeloma
• D. Marfan's syndrome

Explanation: The combination of bone pain, osteitis fibrosa cystica, pathological fractures and renal stones is classic for hyperparathyroidism…

• A. Scurvy
• B. Diabetes mellitus
• C. Myxoedema
• D. Vitamin A deficiency

Explanation: Polyuria, pruritus and recurrent infections or gingival abscesses strongly suggest diabetes mellitus, where hyperglycaemia impairs host…

• A. hypothyroidism
• B. hyperthyroidism
• C. hypoparathyroidism
• D. hyperparathyroidism

Explanation: Excess parathyroid hormone increases bone resorption, producing generalized loss or thinning of the lamina dura.

• A. Microdontia
• B. Defective calcification
• C. Widening of predentin
• D. Inter globular dentin formation

Explanation: Vitamin D deficiency impairs mineralization, causing defective calcification, widened predentin and interglobular dentin.

• A. eosinophils
• B. Histiocytes
• C. Lymphocytes
• D. Fibroblast

Explanation: Eosinophilic granuloma is a localized form of Langerhans cell histiocytosis, resulting from proliferation of abnormal histiocytes or…

• A. Hyper phosphtasia
• B. Hypophosphatemia
• C. Hypophosphatasia
• D. Hyperparathryroidism

Explanation: Hypophosphatasia causes defective mineralization and weak attachment of teeth to alveolar bone, leading to premature loss of primary…

• A. Atrophic glossitis
• B. Oral submucous fibrosis
• C. Syphilitic glossitis
• D. Hurler's syndrome

Explanation: Hurler syndrome causes storage of mucopolysaccharides in connective tissues and may produce macroglossia.

• A. Sickle cell anemia
• B. Hand-Schuller-Christian disease
• C. Littere Siewe Disease
• D. Niemen pick disease

Explanation: The combination of diabetes insipidus, skull or other bone lesions and exophthalmos is the classic triad of Hand-Schüller-Christian…

• A. Vitamin A
• B. Vitamin D
• C. Vitamin C
• D. Vitamin B

Explanation: Vitamin C deficiency causes defective collagen formation, resulting in swollen, bleeding and poorly healing gingiva as seen in scurvy.

• A. Vit - K
• B. Vit - B
• C. Vit - C
• D. Vit - A

Explanation: Vitamin A maintains epithelial differentiation and prevents abnormal keratinization; its deficiency can also produce salivary-gland…

• A. Adrenal cortex
• B. Adrenal medulla
• C. Post pituitary
• D. Parathyroid gland

Explanation: Addison's disease results from inadequate production of adrenal cortical hormones, especially cortisol and aldosterone.

• A. Vit - K
• B. Vit - D
• C. Vit - C
• D. Vit - A

Explanation: Vitamins A, C and D have recognized roles in enamel, dentin and mineralized tooth development.

• A. Juvenile Periodontitis
• B. Cyclic neutropenia
• C. Hypophosphatasia
• D. Papillion Lefevre syndrome

Explanation: Hypophosphatasia is caused by deficiency of tissue-nonspecific alkaline phosphatase, impairing mineralization and causing premature loss…

• A. Rickets
• B. Cherubism
• C. Cleidocranial dysplasia
• D. Congenital hyperthyroidism

Explanation: Rickets, cleidocranial dysplasia and cherubism can delay eruption. Congenital hyperthyroidism is not the typical endocrine cause of…

• A. Candidiasis
• B. Necrotising ulcerative gingivtis
• C. Actinomycosis
• D. Apthous ulcers

Explanation: Prolonged antibiotic therapy suppresses normal bacterial flora, allowing Candida to overgrow and produce oral candidiasis.

• A. Histoplasmosis
• B. Mycormycosis
• C. Candidiasis
• D. None of the above

Explanation: Uncontrolled diabetes predisposes to mucormycosis, a severe opportunistic fungal infection that may invade the nose, sinuses and facial…

• A. Eosinophils
• B. Macropages
• C. Plasma cells
• D. T Lymphocytes

Explanation: T lymphocytes, particularly cell-mediated immunity, are important in controlling Candida, so T-cell deficiency predisposes to persistent…

• A. Acrodynia
• B. Pemphigus vulgaris
• C. Epidermolysis Bullosa
• D. Erosive lichen planus

Explanation: Acrodynia is mercury poisoning, classically associated with fever, painful oral changes, excessive sweating and desquamation of the hands…

• A. Cleidocranial dysostoses
• B. Sturge - weber syndrome
• C. Paget's disease
• D. Mc Cline - Albright syndrome

Explanation: Sturge-Weber syndrome may show tram-line or tram-track calcification caused by intracranial leptomeningeal angiomas, typically in the…