Free Oral Manifestations of Systemic Disease MCQs with Answers

• A. Alport syndrome
• B. Ehlers-Danlos syndrome
• C. Marfan syndrome
• D. McArdle's disease

Explanation: McArdle disease is a glycogen storage disorder caused by muscle phosphorylase deficiency, not a connective-tissue disorder.

• A. Autosomal dominant inheritance
• B. Inability to repair sunlight induced damage to DNA
• C. Irregular accemulation of melanin in the basal cell layer
• D. Acanthosis of epithelium with elongation of rete ridges

Explanation: Xeroderma pigmentosum results from defective nucleotide-excision repair, so ultraviolet-induced DNA damage accumulates and greatly…

• A. Lichen planus
• B. sarcoidosis
• C. pyostomatitis vegentanus
• D. Dermatitis herpetiformis

Explanation: Pyostomatitis vegetans is a characteristic oral manifestation of inflammatory bowel disease, especially ulcerative colitis.

• A. Von Reklinghausen's neurofibromatosis
• B. Albright's syndrome and Bloom's syndrome
• C. None of the above
• D. All of the above

Explanation: Café-au-lait macules are classic in neurofibromatosis type 1 and also occur in McCune-Albright syndrome and Bloom syndrome.

• A. Systemic lupus erythematosus
• B. Herpes simplex
• C. Scleroderma
• D. None of the above

Explanation: The malar or butterfly rash is a classic cutaneous feature of systemic lupus erythematosus, extending across the cheeks and bridge of the…

• A. Down's syndrome
• B. Ehler's Danlos syndrome
• C. Marfan syndrome
• D. Apert's syndrome

Explanation: Ehlers-Danlos syndrome is associated with dentinal abnormalities and multiple pulp stones, often due to altered dentin formation.

• A. Rhematoid arthritis
• B. Psoriasis
• C. Systemis lupus eythematosus
• D. Multicentric reticulohisticytosis

Explanation: Systemic lupus erythematosus commonly causes non-erosive inflammatory arthritis, unlike rheumatoid arthritis, psoriatic arthritis and…

• A. Lupus erythematosus
• B. Lichen planus
• C. Dystrophic epidermolysis bullosa
• D. Scleroderma

Explanation: Scleroderma may produce dystrophic calcification, particularly in areas of chronic tissue damage, known as calcinosis.

• A. Parry Romberg syndrome
• B. Scleroderma
• C. Miescher's syndrome
• D. peutz-Jeghers syndrome

Explanation: Parry-Romberg syndrome, or progressive hemifacial atrophy, causes wasting of the skin, fat, muscle, cartilage and bone on one side of the…

• A. pemphigus vulgaris
• B. Lupus erythematosus
• C. Psoriasis
• D. Herpangina

Explanation: Pinpoint bleeding after removing a psoriatic scale is Auspitz sign, caused by exposed, fragile capillaries in the elongated dermal…

• A. lupus vulgaris
• B. Benign median rhomboid glossitis
• C. Lupus erythematosus
• D. Geographic tongue

Explanation: Psoriasis may be associated with geographic tongue, which produces migrating erythematous depapillated areas with white borders.

• A. Autoimmune disorder
• B. Degenerative condition
• C. Reactive lesion
• D. Neoplastic condition

Explanation: Lupus erythematosus results from loss of immune tolerance with autoantibody formation and immune-complex injury, making it an autoimmune…

• A. A hard and a rigid tongue
• B. Widening of the oral aperture
• C. Pseudo ankylosis of the T.M joint
• D. Difficulty in swallowing

Explanation: Scleroderma causes tightening of facial and oral tissues, producing microstomia or narrowing rather than widening of the oral aperture.

• A. Hyperpyrexia
• B. Protuberant lips and frontal bossing
• C. Any of the above
• D. Defective or absence of sweat glands

Explanation: Ectodermal dysplasia can cause absent or defective sweat glands, resulting in impaired sweating and hyperpyrexia, together with…

• A. Rheumatic heart disease
• B. Infective endocarditis
• C. Ischemic heart disease
• D. Systemic Lupus Erythematosus

Explanation: LE cells are phagocytic neutrophils containing a homogenous, antibody-coated nuclear remnant, classically associated with systemic lupus…

• A. Lichen planus
• B. White sponge nevus
• C. Pemphigus yulgaris
• D. Bullous pemphigoid

Explanation: White sponge nevus is an inherited keratin disorder transmitted as an autosomal dominant trait, commonly presenting as bilateral thickened…

• A. Tightening of oral mucosa and periodontal involvement
• B. Multiple palmar keratosis
• C. All of the above
• D. Raynaud's phenomenon

Explanation: Scleroderma causes tightening and fibrosis of the oral mucosa, periodontal changes, Raynaud's phenomenon, and hyperkeratotic changes such…

• A. Epidermolysis bullose
• B. Syphilis
• C. Darier-White disease
• D. Ehlers-Danlos syndrome

Explanation: Ehlers-Danlos syndrome causes defective collagen and marked tissue laxity, producing hyperextensible skin and an unusually extensible…

• A. Hypertension, diabetes, lichen planus
• B. Oral, ocular, genital lesions
• C. Hypertension with oral lesions
• D. lemphigus, CHF, diabetes

Explanation: Grinspan syndrome traditionally refers to the association of lichen planus with hypertension and diabetes mellitus.

• A. calcinosis cutis
• B. Endocrine disorders
• C. Telagietasis
• D. Raynaud's phenomenon

Explanation: CREST stands for calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.