Xeroderma pigmentosum is characterized by:___________?
Correct answer: B. Inability to repair sunlight induced damage to DNA
- A. Autosomal dominant inheritance
- B. Inability to repair sunlight induced damage to DNA
- C. Irregular accemulation of melanin in the basal cell layer
- D. Acanthosis of epithelium with elongation of rete ridges
Explanation
Xeroderma pigmentosum results from defective nucleotide-excision repair, so ultraviolet-induced DNA damage accumulates and greatly increases skin and ocular cancers. It is usually autosomal recessive, not autosomal dominant.
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