Which phase of hepatic drug metabolism commonly involves conjugation with glucuronic acid?
Correct answer: A. Phase II
- A. Phase II
- B. Phase I
- C. Phase III
- D. Phase zero
Explanation
Glucuronidation is a Phase II conjugation reaction that generally produces a more water-soluble metabolite. Phase I reactions include oxidation, reduction and hydrolysis, whereas Phase III commonly refers to transport and excretion processes.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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