Ketamine produces anaesthesia mainly through antagonism of which receptor?
Correct answer: B. N-methyl-D-aspartate receptor
- A. Nicotinic acetylcholine receptor
- B. N-methyl-D-aspartate receptor
- C. GABA-A receptor
- D. Mu opioid receptor
Explanation
Ketamine is a dissociative anaesthetic that mainly blocks N-methyl-D-aspartate receptors, reducing excitatory glutamate transmission. GABA-A activity is more characteristic of drugs such as propofol and many benzodiazepines.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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