Which pharmacokinetic process converts a lipid-soluble drug into a more water-soluble metabolite for excretion?
Correct answer: C. Hepatic biotransformation
- A. Plasma protein binding
- B. Gastrointestinal absorption
- C. Hepatic biotransformation
- D. Tissue redistribution
Explanation
Hepatic biotransformation chemically modifies many lipid-soluble drugs, usually making them easier to eliminate in urine or bile. Plasma protein binding and tissue redistribution affect drug movement but do not directly produce the main metabolic change.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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