Propofol usually causes a short anaesthetic effect after a single intravenous injection mainly because of which process?
Correct answer: D. Rapid redistribution from the brain to other tissues
- A. Irreversible destruction of central receptors
- B. Permanent binding to plasma proteins
- C. Slow conversion into an inactive metabolite
- D. Rapid redistribution from the brain to other tissues
Explanation
After intravenous administration, propofol rapidly leaves the brain and redistributes into muscle and fat, causing recovery from the initial effect. Metabolism also occurs, but redistribution is especially important after a single bolus.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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