All Free Oral Pathology and Medicine MCQs with Answers

• A. Lichen planus
• B. Pemphigus vulgari
• C. Bullous pemphigoid
• D. Verrucous vulgaris

Explanation: Pemphigus vulgaris involves IgG autoantibodies against desmosomal proteins in the intercellular cementing substance, producing…

• A. Leukoedema
• B. Leukoplakia
• C. Lichen planus
• D. Erythema multiformae

Explanation: Wickham's striae are fine, white, lace-like lines produced by lichen planus.

• A. Erythema multiforma
• B. None of the above
• C. SLE
• D. Steven Johnson syndrome

Explanation: Stevens-Johnson syndrome classically causes severe mucosal involvement of the oral, ocular and genital sites, often with skin lesions.

• A. Can undergo malignant change
• B. Treated only by medication
• C. Must be excised
• D. Is a idiosyncrasy reaction

Explanation: Lichen planus, particularly persistent erosive disease, carries a small risk of malignant transformation to oral squamous cell carcinoma.

• A. Bullous pemphigoid
• B. pemphigus
• C. Bullous lichen planus
• D. Pemphigoid

Explanation: Pemphigus produces an intraepithelial bulla because autoantibodies disrupt desmosomal adhesion between epithelial cells.

• A. Pemphigus vulgaris
• B. Lichenplanus
• C. Erythema multiforme
• D. Psoriasis

Explanation: Target or iris lesions are the hallmark skin lesions of erythema multiforme.

• A. Herpangina
• B. Herpes zoster
• C. Herpes simplex
• D. Stevens Jhonson syndrome

Explanation: Severe bullae, target lesions with an erythematous halo, and oral, ocular or genital mucosal involvement indicate Stevens-Johnson…

• A. Monilial gingivitis
• B. Desquamative gingivitis
• C. Herpetic gingivitis
• D. Acute ulcerative gingivitis

Explanation: Erosive lichen planus commonly presents as desquamative gingivitis, with painful erythematous and ulcerated gingiva.

• A. Both B & C
• B. pemphigus vulgaris
• C. Lupus erythematosus
• D. Scleroderma
• E. Psoriasis

Explanation: Direct immunofluorescence is positive in pemphigus vulgaris, showing intercellular IgG in a fish-net pattern, and in lupus erythematosus…

• A. Atrophic lichen planus
• B. Hypertrophic lichen planus
• C. bullous lichen planus
• D. Verrucous lichen planus

Explanation: Recognized lichen planus variants include atrophic, hypertrophic and bullous forms.

• A. Pemphigus
• B. Bullous pemphigoid
• C. Candida albicans
• D. Lichen planus

Explanation: Pemphigus causes acantholysis, with loss of cohesion between epithelial cells and formation of an intraepithelial, usually suprabasal…

• A. betel nut chewing
• B. intake of certain drugs
• C. cigarette smoking
• D. intake of alcohol

Explanation: Lichenoid reactions are most commonly medication-related, with drugs producing lesions that resemble idiopathic lichen planus clinically…

• A. Mixed cellular inflammatory infiltrate
• B. Antiepithelial antibodies
• C. Presence of T-lymphocytes predominantly
• D. Scattered infiltrate with ill-defined lower border

Explanation: Lichen planus is a T-cell-mediated interface mucositis, so histology shows a dense, predominantly T-lymphocytic band beneath the…

• A. Acanthosis
• B. Hyperparakeratosis
• C. Hyperorthokeratosis
• D. Acantholysis

Explanation: Pemphigus is defined histologically by acantholysis, the breakdown of desmosomal attachment between epithelial cells, producing an…

• A. painless vesicular self limiting disease
• B. An acute self limiting disease, of skin and oral mucous membrane
• C. A viral disease
• D. Bacterial infection

Explanation: Erythema multiforme is an acute, usually self-limiting inflammatory reaction affecting skin and mucous membranes, often producing target…

• A. Pernicious anaemia
• B. Rickets with involvement of teeth and bones
• C. Vitamin A deficiency and involvement of oral epithelium and skin
• D. Diffuse tender ulceration on the palate predominantly

Explanation: Darier disease is an inherited disorder of keratinization involving the skin and sometimes the oral epithelium, with features resembling…

• A. Erythema multiforme
• B. Pemphigoid
• C. Impetigo
• D. Psoriasis

Explanation: Koebner's phenomenon is the appearance of lesions at sites of trauma, classically seen in psoriasis and also possible in lichen planus and…

• A. Lichen planus
• B. ANUG
• C. Apthous disease
• D. pemphigus

Explanation: A Tzanck smear in pemphigus shows acantholytic Tzanck cells, supporting the diagnosis of an intraepithelial blistering disorder.

• A. Verrucous
• B. Hypertrophic
• C. Atrophic
• D. Erosive

Explanation: Atrophic, hypertrophic, and erosive forms are recognized clinical patterns of lichen planus, whereas verrucous is not usually listed as a…

• A. Macule
• B. Bulla
• C. Papule
• D. Nodule

Explanation: A bulla is a fluid-filled elevation larger than a vesicle, whereas a macule is flat and a papule or nodule is solid.