In which of the following disorders a circulating antibody directed to intercellular cementing substance of stratified squamous epithelium is observed:_________?
Correct answer: D. Pemphigus vulgari
- A. Lichen planus
- B. Verrucous vulgaris
- C. Bullous pemphigoid
- D. Pemphigus vulgari
Explanation
Pemphigus vulgaris involves IgG autoantibodies against desmosomal proteins in the intercellular cementing substance, producing intraepithelial acantholysis. Bullous pemphigoid instead targets components of the basement membrane zone.
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