Asked in Premeth Test 22 — Carboxylic Acids, Alcohols and Phenols (24 March 2025) 2025Moderate

Which sequence of groups replace OH of carboxylic acid to halides, esters and amides respectively:

Correct answer: B. -X, -OR, -NH2

  • A. -OH, -X, -NH2
  • B. -X, -OR, -NH2
  • C. -NH2, -H, -X
  • D. -X, -OR, -NO2

Explanation

Carboxylic acid derivatives are formed by replacing the -OH group. Replacing it with a halogen (-X) gives an acid halide. Replacing it with an alkoxy group (-OR) gives an ester. Replacing it with an amino group (-NH2) gives an amide.

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About Carboxylic Acid Derivatives

Carboxylic acid derivatives include acid halides, acid anhydrides, esters and amides, formed by replacing the hydroxyl group of a carboxylic acid. Their nomenclature, structures, preparation, hydrolysis and relative reactivity are linked through nucleophilic acyl substitution, which differs from the nucleophilic addition reactions of aldehydes and ketones.

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