Asked in Premeth Test 22 — Carboxylic Acids, Alcohols and Phenols (24 March 2025) 2025Moderate

When acetic acid reacts with ammonia the attacking nucleophile and the electrophilic center are:

Correct answer: C. N and Carbonyl C

  • A. O and carbonyl C
  • B. O and Carbonyl O
  • C. N and Carbonyl C
  • D. N and Carbonyl O

Explanation

In the reaction between acetic acid (CH3COOH) and ammonia (NH3), the nitrogen atom in ammonia acts as the nucleophile, attacking the electrophilic carbonyl carbon of the acetic acid. The carbonyl carbon is particularly electrophilic due to the partial positive charge created by the electronegative oxygen atom. Thus, the correct answer is that the attacking nucleophile is nitrogen (N) and the electrophilic center is the carbonyl carbon (C).Option A is incorrect because it confuses the nucleophile with an oxygen atom that isn't involved in the reaction. Option B incorrectly identifies the nucleophile and also misstates the electrophilic center. Option D correctly identifies nitrogen but wrongly claims that the electrophile is the carbonyl oxygen, which does not participate in the nucleophilic attack.

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About Carboxylic Acid Derivatives

Carboxylic acid derivatives include acid halides, acid anhydrides, esters and amides, formed by replacing the hydroxyl group of a carboxylic acid. Their nomenclature, structures, preparation, hydrolysis and relative reactivity are linked through nucleophilic acyl substitution, which differs from the nucleophilic addition reactions of aldehydes and ketones.

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