Which hepatic effect is commonly produced by long-term phenobarbital therapy in animals?
Correct answer: B. Induction of microsomal enzymes
- A. Inhibition of microsomal enzymes
- B. Induction of microsomal enzymes
- C. Permanent reduction of renal filtration
- D. Complete blockage of biliary secretion
Explanation
Phenobarbital induces hepatic microsomal enzymes, especially cytochrome P450 enzymes. This can increase the metabolism of other drugs and may reduce their duration of action.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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