Local anaesthetics prevent nerve impulse transmission mainly by blocking which channel?
Correct answer: C. Voltage-gated sodium channels
- A. Voltage-gated calcium channels
- B. Ligand-gated chloride channels
- C. Voltage-gated sodium channels
- D. ATP-sensitive potassium channels
Explanation
Local anaesthetics block voltage-gated sodium channels in neuronal membranes. This prevents depolarisation and stops propagation of the action potential along the nerve.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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