Furosemide produces diuresis primarily by inhibiting sodium and chloride reabsorption in which nephron segment?
Correct answer: C. Thick ascending loop of Henle
- A. Proximal convoluted tubule
- B. Distal convoluted tubule
- C. Thick ascending loop of Henle
- D. Collecting duct
Explanation
Furosemide blocks the sodium-potassium-2 chloride cotransporter in the thick ascending limb of the loop of Henle. This reduces the medullary concentration gradient and produces marked diuresis.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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