Two parents hemophilic and other carrier, chances among the male offspring to be hemophilic:
Correct answer: B. 50%
- A. 25%
- B. 50%
- C. 75%
- D. 100%
Explanation
Haemophilia is a sex-linked recessive disorder, usually an inherited bleeding disorder in which the blood does not clot properly. According to the question, among male offspring 50% are normal and 50% are hemophilic as inherits the haemophilia X chromosome from carrier mother.
This question appeared on the HEC Phase I 2017 paper, which you can sit online with every answer explained.
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About X-linked Recessive Inheritance
X-linked recessive inheritance involves genes on the X chromosome, so males express a recessive allele with no corresponding allele on their single X chromosome, while females may be carriers. Pedigrees cover haemophilia and red-green colour blindness, including carrier mothers, affected sons and the absence of father-to-son transmission.
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