The reaction inhibited in thiamine deficiency is_______________?
Correct answer: A. Pyruvate to acetyl CoA
- A. Pyruvate to acetyl CoA
- B. Citrate to alpha ketoglutarate
- C. Succinyl CoA to fumarate
- D. None of the above
Explanation
Thiamine pyrophosphate, the active form of vitamin B1, is required by pyruvate dehydrogenase for conversion of pyruvate to acetyl-CoA. Thiamine deficiency therefore impairs this reaction and can cause lactic acidosis.
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