Asked in KMU MDCAT 2023 2023Moderate

Tay-Sach's disease particularly results from the malfunctioning of:

Correct answer: C. Lysosomes

  • A. Cell membrane
  • B. Nucleus
  • C. Lysosomes
  • D. Vacuole

Explanation

Option C is correct.Tay-Sach's disease particularly results from the malfunctioning of lysosomes. Lysosomes are cellular organelles that contain enzymes that break down complex molecules, such as carbohydrates, proteins, and lipids. In Tay-Sach's disease, there is a deficiency of the enzyme hexosaminidase A, which is essential for the breakdown of a fatty substance called GM2 ganglioside. As a result, GM2 ganglioside accumulates in lysosomes, causing damage to nerve cells and other tissues. Tay-Sach's disease is a genetic disorder that is inherited from both parents. It is a rare disease, but it is more common in people of Ashkenazi Jewish descent. There is no cure for Tay-Sach's disease, but there are treatments that can help manage the symptoms and improve the quality of life for people with the disease. The other options are not directly involved in the malfunctioning that causes Tay-Sach's disease: The cell membrane is a barrier that surrounds the cell and protects it from the external environment. The nucleus is the central organelle of the cell and contains the cell's DNA. Vacuoles are fluid-filled sacs that store water, nutrients, and waste products.

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