Sulfonamide antibacterials inhibit bacterial growth primarily by blocking which metabolic pathway?
Correct answer: D. Folate synthesis
- A. Cholesterol formation
- B. Peptidoglycan breakdown
- C. Bile acid synthesis
- D. Folate synthesis
Explanation
Sulfonamides inhibit dihydropteroate synthase, an enzyme required for bacterial folate synthesis. They do not directly break down peptidoglycan or inhibit animal cholesterol metabolism.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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