A drug that is highly bound to plasma proteins generally has which immediate pharmacokinetic characteristic?
Correct answer: B. A smaller free fraction in plasma
- A. Complete renal filtration
- B. A smaller free fraction in plasma
- C. Rapid entry into cerebrospinal fluid
- D. Unrestricted tissue penetration
Explanation
Only the unbound fraction of a drug is readily available for distribution, metabolism and renal filtration. Extensive protein binding therefore reduces the immediate free fraction, although equilibrium can later release bound drug.
Report an error
The more specific you are, the faster it gets fixed. A source beats an opinion.
Prefer email? support@testustad.com
About Veterinary Pharmacology
Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
Practise Veterinary Pharmacology
60 free Veterinary Pharmacology MCQs from Veterinary Science, each with the correct answer and an explanation. Unlimited attempts, no account needed.
Discussion
Stuck on an option, or know a faster way to get there? Ask or explain it here.
No comments yet. Be the first to explain this one.
Exams that ask Veterinary Science questions like this
Veterinary Science is on this paper prepared for on TestUstad, and all of them draw the same bank, so this question is worth knowing for it.
More Veterinary Pharmacology questions
Which adverse effect is classically associated with excessive digoxin administration in animals?
Which drug is most likely to undergo extensive binding to plasma albumin and show displacement interactions with other drugs?
The bronchodilator action of aminophylline is mainly related to inhibition of which enzyme?
Benzodiazepines produce sedation and muscle relaxation mainly by enhancing the action of which neurotransmitter?
Sulfonamide antibacterials inhibit bacterial growth primarily by blocking which metabolic pathway?
Which drug is commonly used as an antidote for ethylene glycol poisoning in dogs?