Metoclopramide produces much of its antiemetic effect by blocking which receptor in the chemoreceptor trigger zone?
Correct answer: D. Dopamine D2 receptor
- A. GABA-A receptor
- B. Histamine H1 receptor
- C. Opioid mu receptor
- D. Dopamine D2 receptor
Explanation
Metoclopramide mainly reduces vomiting through dopamine D2 receptor antagonism in the chemoreceptor trigger zone. It also has gastrointestinal prokinetic actions, but these do not identify its main antiemetic receptor mechanism.
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Covers how drugs act in animals, including pharmacokinetics, pharmacodynamics, routes of administration, dosage forms, adverse effects and drug interactions. Major groups include antimicrobials, antiparasitics, analgesics, anaesthetics, anti-inflammatory drugs, hormones and cardiovascular medicines, with attention to withdrawal periods and species differences.
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