Asked in PMC Practice Test 13 (2021) 2021Moderate

Lock and Key model was proposed by which of the following?

Correct answer: D. Emil Fischer

  • A. Koshland
  • B. Robin Williams
  • C. Rudolph Virchow
  • D. Emil Fischer

Explanation

The lock and key model was proposed by Emil Fischer who was a german scientist and receiver of the nobel prize in chemistry. He also developed the Fischer esterification and projection.

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About Mode of Enzyme Action

Enzyme action depends on the active site forming a temporary enzyme substrate complex, then converting substrate into products with lower activation energy. The lock and key and induced fit models explain specificity and binding, while cofactors and changes in enzyme shape can affect catalysis.

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