Which of the following statements about the lock and key model is INCORRECT?
Correct answer: D. The enzyme can react with a wide range of substrates
- A. The active site is rigid in nature
- B. The active site is complementary to substrate
- C. The enzyme can react with specific substrates only
- D. The enzyme can react with a wide range of substrates
Explanation
In the lock and key model of enzyme action, the enzyme's active site is specifically shaped to fit only its corresponding substrate, much like a key fits into a specific lock. This model highlights the specificity of enzyme-substrate interactions, where each enzyme is designed to catalyze a reaction with a particular substrate. The active site is considered to be rigid and complementary to the substrate, allowing only matching substrates to bind effectively. Therefore, the statement that the enzyme can react with a wide range of substrates is incorrect, as it contradicts the core concept of specificity in the lock and key model. The other options correctly describe aspects of the model, such as the rigidity of the active site and the specificity of enzyme-substrate interactions.
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About Mode of Enzyme Action
Enzyme action depends on the active site forming a temporary enzyme substrate complex, then converting substrate into products with lower activation energy. The lock and key and induced fit models explain specificity and binding, while cofactors and changes in enzyme shape can affect catalysis.
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