Asked in HEC Phase II 2017 2017Moderate

What describes the induced fit model of action of an enzyme?

Correct answer: A. The binding of the active site to the substrate causes the enzyme to change shape

  • A. The binding of the active site to the substrate causes the enzyme to change shape
  • B. The substrate and active site have complementary shapes that form temporary bonds
  • C. The substrate causes a change in enzymes shape so the active site can bind
  • D. The substrate changes shape so it can bind to the active site

Explanation

a) The binding of the active site to the substrate causes the enzyme to change shape:This option describes the induced fit model accurately. According to this model, when the substrate binds to the active site of the enzyme, both the enzyme and the substrate undergo conformational changes. The binding induces a change in the shape of the enzyme, resulting in a tighter fit between the enzyme and substrate.

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About Mode of Enzyme Action

Enzyme action depends on the active site forming a temporary enzyme substrate complex, then converting substrate into products with lower activation energy. The lock and key and induced fit models explain specificity and binding, while cofactors and changes in enzyme shape can affect catalysis.

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