Asked in Premeth Test 3 — The Cell, Evolution and Enzymes (5 March 2025) 2025Moderate

Follow the route of pepsinogen secreted by zymogen cells:

Correct answer: B. RER → SER → Golgi complex → Secretory vesicles

  • A. SER → Mitochondria → Golgi complex → Secretory vesicles
  • B. RER → SER → Golgi complex → Secretory vesicles
  • C. SER → RER → Golgi complex → Secretory vesicle
  • D. Golgi complex → RER → SER → Secretory vesicles

Explanation

This statement is correct because proteins destined for secretion or membrane insertion are synthesized on the Rough Endoplasmic Reticulum (RER). From the RER, they are transported to the Smooth Endoplasmic Reticulum (SER) and then to the Golgi complex. In the Golgi complex, proteins undergo modification, such as glycosylation and phosphorylation. After modification, the proteins are packaged into secretory vesicles. These vesicles then fuse with the plasma membrane, releasing the proteins outside the cell or inserting them into the membrane. This process illustrates the important role of the ER and Golgi complex in protein synthesis and secretion.

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