A patient with severe renal impairment receives a drug that is mainly eliminated through the kidneys. Which prescription-related concern should the nurse raise?
Correct answer: A. The drug may accumulate and cause toxicity
- A. The drug may accumulate and cause toxicity
- B. The drug will always be absorbed poorly
- C. The drug will be destroyed in the stomach
- D. The drug will have no therapeutic effect
Explanation
Reduced renal function can slow drug excretion, causing accumulation and toxicity. Poor absorption and destruction in the stomach are not expected simply because renal function is impaired.
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About Principles of Pharmacology
Pharmacology examines drug sources, names, dosage forms, mechanisms of action, absorption, distribution, metabolism and excretion. Questions cover pharmacokinetics versus pharmacodynamics, therapeutic effects, adverse reactions, contraindications, drug interactions, tolerance, dependence and the safety responsibilities of the nurse.
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