A patient taking pyrazinamide for tuberculosis reports severe pain and swelling in the great toe. Which adverse effect should the nurse suspect?
Correct answer: A. Hyperuricaemia with gout-like pain
- A. Hyperuricaemia with gout-like pain
- B. Severe hypoglycaemia from insulin release
- C. Ototoxicity with vestibular damage
- D. Aplastic anaemia from marrow failure
Explanation
Pyrazinamide can increase uric acid and cause arthralgia or gout-like symptoms. Ototoxicity is more associated with aminoglycosides, while hypoglycaemia and aplastic anaemia are not its typical major effects.
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About Antimicrobial Drugs
Antimicrobial pharmacology covers antibiotics, antitubercular, antifungal, antiviral and antiparasitic drugs, including their targets, clinical uses, resistance and major adverse effects. Questions distinguish bactericidal from bacteriostatic action, narrow from broad spectrum therapy, and antimicrobial treatment from supportive management of infection.
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