Free Systemic Pathology MCQs with Answers

• A. Formation of sinusoids
• B. Vitamin-A storage
• C. Increases blood perfusion
• D. PhagocytosisConsult Online Doctors

Explanation: Kupffer cells are specialised macrophages lining the hepatic sinusoids, where they remove bacteria, aged blood cells, and particulate…

• A. Actinomyces israeli
• B. Mycobacterium leprae
• C. Mycobacterium bovis
• D. All of the above

Explanation: Actinomyces israelii is a filamentous, branching bacterium that resembles a fungus and forms sulfur granules in tissue.

• A. Sarcoidosis
• B. Diphtheria
• C. Tuberculosis
• D. Actinomycosis

Explanation: The Kveim test uses an extract of sarcoid tissue and was historically used to support the diagnosis of sarcoidosis.

• A. Primary
• B. Tetriary
• C. Secondary
• D. Congenital

Explanation: Secondary syphilis has the highest infectivity because widespread spirochetemia produces abundant organisms in mucocutaneous lesions.

• A. Comminuted fracture
• B. Compound fracture
• C. Simple fracture
• D. Green stick fracture

Explanation: A greenstick fracture is an incomplete break in which the bone bends and cracks, commonly occurring in children because their bones are…

• A. Pagets disease
• B. Osteomyelitis
• C. Fibrous dysplasia
• D. Achondroplasia

Explanation: Paget disease of bone classically produces a cotton-wool appearance on skull radiographs because of irregular, mixed lytic and sclerotic…

• A. Ossifying fibroma
• B. Aneurysmal bone cyst
• C. Fibrous dysplasia
• D. None of the above

Explanation: An aneurysmal bone cyst produces an expansile, eccentric, ballooned-out lesion filled with blood-filled spaces.

• A. Thyroid
• B. Kidney
• C. Prostate
• D. Uterus

Explanation: Prostatic carcinoma classically produces osteoblastic, bone-forming metastases, especially in the spine and pelvis.

• A. Fibro sarcoma
• B. Osteosarcoma
• C. Osteoma
• D. Ewing's sarcoma

Explanation: Ewing sarcoma classically causes an onion-skin periosteal reaction due to repeated layers of reactive new bone formation.

• A. Serum LDH
• B. Serum CPK
• C. Serum SGOT
• D. Serum SGPT

Explanation: LDH remains elevated for several days after myocardial infarction and reaches its peak around the second to third day, whereas CPK may…

• A. jaundice
• B. Haemosiderosis
• C. Kernicterus
• D. All of the above

Explanation: Kernicterus is bilirubin deposition in the basal ganglia and other brain regions, usually in severe neonatal unconjugated…

• A. Scanning electron miscroscopy
• B. Electron microscopy
• C. X-ray crytallography
• D. Polarized microscopy

Explanation: Amyloid is confirmed with Congo red staining showing apple-green birefringence under polarized light.

• A. Increase in osteoid maturation time
• B. Decrease in osteoid surface
• C. Decrease in osteoid volume
• D. Increase in mineral apposition rate

Explanation: Osteomalacia is defective mineralization of newly formed osteoid, so osteoid maturation time increases and mineral apposition falls.

• A. Actinomycosis
• B. Tuberculosis
• C. Rabies
• D. Secondary Iues

Explanation: Secondary amyloidosis is caused by prolonged inflammation or infection, and tuberculosis is a classic underlying disease.

• A. Hydropic degeneration
• B. Amyloid degeneration
• C. Hyaline degeneartion
• D. Fatty degeneration

Explanation: Mallory-Denk bodies are eosinophilic cytoplasmic aggregates of damaged intermediate filaments in hepatocytes.

• A. AL protein
• B. a2 microglobulin
• C. a-amyloid protein
• D. Transthyretin

Explanation: Senile systemic amyloidosis is caused by deposition of wild-type transthyretin, especially in the heart of older adults.

• A. Spleen
• B. Kidney
• C. Liver
• D. Heart

Explanation: The kidney is the commonest and often clinically most important site of systemic amyloid deposition, where it can cause proteinuria and…

• A. Hodgkin's diseaes
• B. Tuberculosis
• C. Multiple myeloma
• D. Chronic osteomyelitis

Explanation: Primary amyloidosis is usually caused by a plasma-cell disorder producing monoclonal immunoglobulin light chains, and it is classically…

• A. Reticulin
• B. Masson's toichrome
• C. Vonkosa
• D. Congo Red

Explanation: Congo red is the standard stain for amyloid and shows apple-green birefringence under polarized light.