Free Haematology MCQs with Answers

• A. Iron deficiency
• B. Aplastic
• C. Sickle cell
• D. Chronic infections

Explanation: Iron deficiency reduces serum iron, while the liver increases transferrin production, causing a raised total iron-binding capacity.

• A. aplastic anemia
• B. megaloblastic anemia
• C. sickle cell anemia
• D. hemolytic anemia

Explanation: Megaloblastic anaemia is commonly nutritional, resulting from folate or vitamin B12 deficiency and producing defective DNA synthesis.

• A. Factor X
• B. Factor VIII
• C. Factor IX
• D. Factor XI

Explanation: Haemophilia A is an X-linked bleeding disorder caused by factor VIII deficiency, whereas factor IX deficiency causes haemophilia B.

• A. Chronic myeloid leukemia
• B. Chronic malaria
• C. Acute lymphoblastic leukemia
• D. Tropical splenomegaly

Explanation: Massive splenomegaly is classically associated with chronic myeloid leukaemia, chronic malaria and tropical splenomegaly.

• A. Thalassemia
• B. Pernicious anemia
• C. Aplastic anemia
• D. Sickle cell anemia

Explanation: Target cells have excess membrane relative to cell volume and are especially characteristic of thalassaemia, where reduced globin…

• A. Folic acid level
• B. B12 malabsroption
• C. Pancreatic enzyme deficiency
• D. Coronary artery disease

Explanation: The Schilling test was designed to assess vitamin B12 absorption by measuring urinary excretion of radiolabelled B12, sometimes with…

• A. Increased bleeding time and clotting time
• B. Decreased bleeding time and clotting time
• C. Normal bleeding time and increased clotting time
• D. Decreased bleeding time and increased clotting time

Explanation: Haemophilia is a coagulation-factor deficiency, so the platelet plug forms normally and bleeding time remains normal, while clotting time…

• A. African jaw lymphoma
• B. Infectious mononucleosis
• C. Burkitt's lymphoma
• D. Hodgkin's disease

Explanation: Reed-Sternberg cells are the characteristic neoplastic cells of classical Hodgkin lymphoma, usually surrounded by a mixed inflammatory…

• A. Idiopathic thrombocytopenic purpura
• B. Christmas disease
• C. Vitamin K deficiency
• D. Classic hemophilia

Explanation: Idiopathic thrombocytopenic purpura causes thrombocytopenia, producing prolonged bleeding time while the coagulation or clotting time…

• A. Ferritin
• B. Transferrin
• C. Myoglobin
• D. Haemosiderin

Explanation: Transferrin is the plasma iron-binding protein that transports absorbed iron from the intestine to tissues and bone marrow.

• A. Chronic lymphoblastic leukemia
• B. Chronic monocytic leukemia
• C. Acute myeloid leukemia
• D. Chronic myeloid leukemia

Explanation: Acute myeloid leukemia can cause gingival infiltration, oral ulcers, bleeding, anemia, hepatomegaly and very high leukocyte counts without…

• A. Levels of factor VIII less than 50% are associated with spontaneous hemorrhage
• B. In hemophilia A females are carriers
• C. Desmopressin is useful in the management of hemophilia A
• D. Hemophilia A is due to deficiency of factor VIII

Explanation: Hemophilia A is due to factor VIII deficiency; desmopressin can help mild cases by releasing stored factor VIII and von Willebrand factor.

• A. One alpha chain and one beta chain
• B. Two alpha chains and two beta chains
• C. One beta chains and two alpha chains
• D. One alpha chains and two beta chains

Explanation: Normal adult hemoglobin A is HbA, composed of two alpha and two beta chains, written α2β2.

• A. Disseminated intravascular coagulation
• B. Aplastic anaemia
• C. Von willebrand disease
• D. Acute myelocytic leukemia

Explanation: DIC, aplastic anemia and acute myelocytic leukemia commonly reduce platelet numbers through consumption, marrow failure or marrow…

• A. Fetal alcohol syndrome
• B. Sickle cell anaemia
• C. Haemophilia A
• D. Beta thalassemia majon

Explanation: Severe ineffective erythropoiesis in beta-thalassemia major causes marked marrow expansion, with enlarged spaces and a characteristic…

• A. All of the above
• B. Beta - Thalassemia major
• C. Erythroblastic anema
• D. Mediterranean anemia

Explanation: Cooley anemia is the severe transfusion-dependent form of beta-thalassemia, also called beta-thalassemia major or Mediterranean anemia.

• A. Osteopetrosis
• B. Haemolytic anaemia
• C. DIsseminated intravascular coagulation
• D. Thiazide therapy

Explanation: Haemolytic anaemia may produce reactive thrombocytosis as the marrow increases blood-cell production after red-cell destruction.

• A. Acute erythroleukaemia
• B. Acute myelomonocytic leukaemia
• C. Acute megakaryocytic leukaemia
• D. Acute promyelocytic leukaemia

Explanation: Acute promyelocytic leukaemia is strongly associated with DIC because abnormal promyelocytes release procoagulant substances and trigger…

• A. Tuberculosis
• B. Pertussis
• C. Viral infections
• D. Lobar pneumonia

Explanation: Lymphocytic leukemoid reactions occur in pertussis, tuberculosis and many viral infections.

• A. Anti thrombin - III deficiency
• B. Haemophilia - B
• C. Haemophilia - A
• D. Von-willebrand disease

Explanation: Haemophilia A, haemophilia B and von Willebrand disease can cause prolonged bleeding after dental extraction because clot formation is…