Free Virology MCQs with Answers

• A. Verruca vulgaris
• B. Focal epithelial hyperplasia
• C. Condyloma acuminatum
• D. Keratoacanthoma

Explanation: Verruca vulgaris, focal epithelial hyperplasia and condyloma acuminatum are recognised HPV-associated lesions.

• A. Hepatitis B virus
• B. Hepatitis C virus
• C. Hepatitis E virus
• D. Hepatitis A virus

Explanation: Hepatitis E is especially dangerous during pregnancy and can cause severe, fulminant hepatic failure.

• A. Sialoperoxidase
• B. Secretory IgA
• C. Salivary leukocyte proteinase inhibitor
• D. Histidine rich proteins

Explanation: Salivary leukocyte protease inhibitor, or SLPI, is an innate salivary protein that inhibits HIV infection and helps explain the very low…

• A. Inactive carrier
• B. Healthy carrier
• C. Convalscent carrier
• D. Paradoxical carrier

Explanation: A convalescent carrier has recovered clinically and may have normal laboratory findings but continues to harbour and transmit the…

• A. Saubourd's agar
• B. Rogosa medium
• C. Nonembryonated egg
• D. Embryonated egg

Explanation: Viruses require living cells for replication, so they can be grown in living systems such as embryonated eggs.

• A. Above 600
• B. Between 1000-2000
• C. Below 200
• D. Above 2000

Explanation: In patients with HIV infection, Kaposi sarcoma is strongly associated with advanced immunosuppression, commonly when the CD4 count falls…

• A. Hanta virus pulmonary syndrome is caused by inhalation of rodent urine and faces
• B. Kyanasur forest disease is caused by bite of wild animal
• C. Lyssa virus is transmitted by ticks
• D. None of the above

Explanation: Hantavirus pulmonary syndrome is acquired mainly by inhaling aerosolised particles from infected rodent urine, faeces, or saliva.

• A. Rubella
• B. Rubeola
• C. Herpes simplex
• D. Herpetic ginglvostomatitis

Explanation: German measles is the common name for rubella, a disease caused by rubella virus. Rubeola refers to measles, not German measles.

• A. IgM antibodies in serum
• B. Isolation form stool
• C. Culture from blood
• D. Isolation from bile

Explanation: Acute hepatitis A is best confirmed by detecting anti-HAV IgM in serum, which appears early in infection.

• A. Cowpox
• B. Molluscum contagiosum
• C. Small pox
• D. chicken pox

Explanation: Chickenpox is caused by varicella-zoster virus, a herpesvirus, whereas cowpox, molluscum contagiosum, and smallpox are caused by…

• A. Surface antigen
• B. Surface antibody
• C. Core antigen
• D. Core antibody

Explanation: HBsAg is the main screening marker for current hepatitis B infection, so its detection is used to estimate prevalence.

• A. Adeno
• B. Hepatitis
• C. EB virus
• D. Parvo virus

Explanation: Parvovirus B19 infects erythroid precursor cells and can temporarily stop red-cell production, causing an aplastic crisis in patients with…

• A. CD8 T-cells
• B. CD4 T-cells
• C. B - cells
• D. NK - cells

Explanation: HIV gp120 attaches first to the CD4 receptor on helper T lymphocytes, followed by interaction with a chemokine coreceptor such as CCR5 or…

• A. HBc Ag
• B. HBs Ag
• C. Hbe Ag
• D. HBx Ag

Explanation: HBxAg refers to the hepatitis B virus X protein, a small nonstructural regulatory protein that transactivates viral and cellular genes and…

• A. Hepatitis A
• B. Hepatitis B
• C. CMV
• D. EBV

Explanation: Cytomegalovirus is a frequent and important opportunistic infection after organ transplantation because immunosuppressive therapy weakens…

• A. Nasopharyngeal carcinoma
• B. Burkitt's lymphoma
• C. Hepatoma
• D. Infectious mononucleosis

Explanation: EBV is associated with infectious mononucleosis, Burkitt lymphoma and nasopharyngeal carcinoma.

• A. Carcinoma
• B. Kaposi's sarcoma
• C. Melanoma
• D. Ewing's sarcoma

Explanation: Kaposi sarcoma, caused by human herpesvirus 8, is a classic AIDS-associated tumour because severe immunosuppression permits HHV-8-driven…

• A. Picorna viruses
• B. Herpes viruses
• C. Hepadana viruses
• D. Flavi viruses

Explanation: Hepatitis C virus is an enveloped, positive-sense RNA virus in the family Flaviviridae.

• A. Tissue culture
• B. Embryonated eggs
• C. Animals
• D. Chemically defined media

Explanation: Viruses require living cells for replication, so they can be grown in tissue culture, embryonated eggs, or experimental animals.

• A. ELISA IS - ve
• B. Western Blot is - ve
• C. Both are - ve
• D. PCR is - ve

Explanation: During the HIV window period, antibodies have not yet reached detectable levels, so both ELISA and Western blot are usually negative.