With prolonged use in seizure states, which of the following drugs can cause coarsening of facial features, hirsutism, gingival hyperplasia and osteomalacia?
Correct answer: D. Phenytoin
- A. Valproic acid.
- B. Carbamazepine.
- C. Ethosuximide.
- D. Phenytoin
Explanation
Long-term phenytoin therapy may cause gingival hyperplasia, hirsutism, coarse facial features, and vitamin-D-related osteomalacia. These characteristic chronic adverse effects distinguish phenytoin from the other listed anticonvulsants.
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