Why is carbidopa combined with levodopa in the treatment of Parkinson disease?
Correct answer: B. It reduces peripheral conversion of levodopa to dopamine
- A. It blocks dopamine receptors in the basal ganglia
- B. It reduces peripheral conversion of levodopa to dopamine
- C. It prevents all involuntary movements caused by levodopa
- D. It directly replaces acetylcholine in skeletal muscle
Explanation
Carbidopa inhibits peripheral conversion of levodopa to dopamine, allowing more levodopa to reach the brain and reducing peripheral adverse effects such as nausea. It does not block dopamine receptors or guarantee prevention of dyskinesias.
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About Analgesics and CNS Drugs
This area covers opioid and non-opioid analgesics, local anaesthetics, sedatives, anxiolytics, antidepressants, antipsychotics, antiepileptics and drugs for Parkinsonism. It examines therapeutic actions, dependence, respiratory depression, extrapyramidal effects, serotonin related toxicity and the distinction between pain relief, sedation and loss of consciousness.
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