Which of the following statements concerning potassium channel openers is true?
Correct answer: F. These agents increase the permeability of K channels, probably ATP-dependent K channels, that results in stabilizing the membrane potential of excitable cells near the resting potential Drugs & Medications
- A. These agents decrease transmembrane calcium current associated in a smooth muscle with long-lasting relaxation
- B. and in a cardiac muscle with a reduction in contractility
- C. These agents has a moderate reflex and vascular dilative action caused by the stimulation of sensitive nerve endings
- D. Beneficial effects of these agents are related primarily to their hemodynamic effects - decreased heart rate, blood
- E. pressure, and contractility - which decrease myocardial oxygen requirements at rest and during exercise
- F. These agents increase the permeability of K channels, probably ATP-dependent K channels, that results in stabilizing the membrane potential of excitable cells near the resting potential Drugs & Medications
Explanation
Potassium-channel openers increase K⁺ permeability, often through ATP-sensitive channels, causing membrane hyperpolarisation and relaxation of vascular smooth muscle. The other statements incorrectly describe calcium-channel blockers or effects such as reduced heart rate and contractility.
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