Which microscopic feature most strongly indicates osteosarcoma in a bone biopsy?
Correct answer: D. Neoplastic cells producing malignant osteoid
- A. Lamellar bone with normal osteocytes
- B. Mature cartilage without cellular atypia
- C. Uniform fat cells between bone trabeculae
- D. Neoplastic cells producing malignant osteoid
Explanation
Malignant osteoid produced directly by atypical neoplastic cells is the defining histological feature of osteosarcoma. Mature cartilage or normal lamellar bone may occur in other lesions but does not establish this diagnosis.
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Covers the causes and mechanisms of disease, cellular injury, inflammation, healing, circulatory disturbances, neoplasia and disorders of major organs. It also includes gross and microscopic pathological changes, specimen interpretation and the distinction between aetiology, pathogenesis, clinical signs and lesions.
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