Which mediator is most directly responsible for producing fever by acting on the hypothalamus?
Correct answer: A. Prostaglandin E2
- A. Prostaglandin E2
- B. Bradykinin
- C. Histamine
- D. Nitric oxide
Explanation
Prostaglandin E2 acts in the hypothalamus to raise the thermoregulatory set point during fever. Interleukin-1 and tumor necrosis factor stimulate this pathway, but prostaglandin E2 is the direct mediator at the hypothalamus.
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