Which histological finding is most characteristic of amyloid deposition?

Correct answer: A. Apple-green birefringence after Congo red staining

  • A. Apple-green birefringence after Congo red staining
  • B. Magenta material with periodic acid Schiff stain only
  • C. Black granules after Prussian blue staining
  • D. Metachromatic material after Gram staining

Explanation

Amyloid deposits bind Congo red and show apple-green birefringence under polarized light, which is a characteristic diagnostic finding. Prussian blue staining is used mainly to demonstrate iron deposits such as hemosiderin.

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