Which drugs had high first pass effect_____________?
Correct answer: C. Verapamil
- A. Amiodarone
- B. Phenytoin
- C. Verapamil
- D. Disorpyamide
Explanation
Verapamil undergoes substantial hepatic first-pass metabolism, so its oral bioavailability is much lower than its parenteral availability. This is why oral doses are higher than equivalent IV doses.
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