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Which antibiotic inhibits the interaction between tRNA and mRNA during bacterial protein synthesis?

Correct answer: C. Neomycin

  • A. Tetracycline
  • B. Erythromycin
  • C. Neomycin
  • D. Streptomycin

Explanation

Neomycin is a broad spectrum antibiotic which was first isolated from a strain of Streptomyces feadiae. It is effective against Gram positive as well as Gram negative bacteria. Its mechanism of action is by selective inhibition of protein synthesis on the 70S (prokaryotic) ribosome by inhibiting the interaction of mRNA and tRNA during translation process. Neomycin can indeed interfere with the interaction between tRNA and mRNA during bacterial protein synthesis. It primarily does so by binding to the ribosome and causing mistranslation or misreading of the mRNA, which leads to the production of incorrect or nonfunctional proteins.

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