Which action describes the main effect of sitagliptin in a patient with type 2 diabetes?
Correct answer: A. It prolongs incretin activity and increases glucose-dependent insulin release
- A. It prolongs incretin activity and increases glucose-dependent insulin release
- B. It replaces basal insulin and provides glucose control for 24 hours
- C. It blocks intestinal glucose absorption before carbohydrates enter the blood
- D. It increases urinary glucose loss by inhibiting renal glucose reabsorption
Explanation
Sitagliptin inhibits dipeptidyl peptidase-4, which prolongs incretin activity and promotes glucose-dependent insulin release. The other actions describe insulin replacement, alpha-glucosidase inhibition and SGLT2 inhibition.
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About Endocrine and Diabetes Drugs
Endocrine pharmacology includes insulin preparations, oral antidiabetic drugs, thyroid and antithyroid medicines, corticosteroids, sex hormones and drugs affecting calcium balance. Questions address onset and duration, administration, monitoring, hypoglycaemia, steroid adverse effects and the difference between replacing a deficient hormone and suppressing excessive hormone activity.
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