A patient taking an aromatase inhibitor for breast cancer asks why bone health is monitored. Which explanation is correct?
Correct answer: A. Reduced oestrogen can accelerate bone loss and increase fracture risk
- A. Reduced oestrogen can accelerate bone loss and increase fracture risk
- B. Increased oestrogen causes excessive calcium deposition in the arteries
- C. The medicine directly blocks calcium absorption in the intestine
- D. The medicine commonly causes parathyroid hormone deficiency
Explanation
Aromatase inhibitors reduce oestrogen production, and low oestrogen promotes bone resorption. Long-term treatment can therefore reduce bone mineral density, so fracture risk and bone health require monitoring.
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About Endocrine and Diabetes Drugs
Endocrine pharmacology includes insulin preparations, oral antidiabetic drugs, thyroid and antithyroid medicines, corticosteroids, sex hormones and drugs affecting calcium balance. Questions address onset and duration, administration, monitoring, hypoglycaemia, steroid adverse effects and the difference between replacing a deficient hormone and suppressing excessive hormone activity.
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