When broad spectrum antibiotics are administered with coumarin anticoagulants, the anticoagulant action may be____________?
Correct answer: C. Increased because of reduction of vitamin sources
- A. Reduced because of enhanced hepatic drug metabolism
- B. Reduced because of increased protein binding
- C. Increased because of reduction of vitamin sources
- D. Increase because of decrease renal excretion of the anticoagulant
Explanation
Broad-spectrum antibiotics reduce intestinal bacteria that normally contribute to vitamin K production, lowering clotting-factor synthesis and enhancing coumarin’s anticoagulant effect. This raises the risk of bleeding rather than reducing anticoagulation.
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