The main enzyme responsible for activation of xenobiotics in (detoxification)____________?
Correct answer: A. Cytochrome P-450
- A. Cytochrome P-450
- B. Glutathione S-transferase
- C. NADPH cytochrome P-450 reductase
- D. Glucuronyl transferase
Explanation
Cytochrome P-450 carries out the major Phase I oxidation reactions that activate or modify many xenobiotics. Glutathione S-transferase and glucuronyl transferase mainly participate in Phase II conjugation reactions.
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