Moderate

McArdles disease is due to the deficiency of_____________?

Correct answer: D. Myophosphorylase

  • A. Glucose 1 phosphatase
  • B. Glucose 1,6 phosphatase
  • C. Glucose 6 phosphatase
  • D. Myophosphorylase

Explanation

McArdle disease is caused by deficiency of muscle glycogen phosphorylase, also called myophosphorylase. This blocks glycogen breakdown in skeletal muscle and causes exercise-induced cramps and myoglobinuria.

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